I have never played real epic campaign. But my last 3.5e campaign reached to 21st-level. And yes, some of the opponents did have 21+ CL.
But the party Sorcerer has Draconic Power feat (CL +1), Ring of Arcane Might (CL +1), CL +1 Ioun Stone (CL +1) and the robe which incleases CL of Abjuration spell by +1. As a result, her Chain Dispel roll was 1d20+25 at level 21st. Another PC, a cleric, had Divine Spellpower feat and often done nearly good.
Well, if I were to play true epic campaign, maybe I will make improved version of dispel spells as 10+ level spells.