D&D is big worldwide. But I know Germany is a somewhat different situation, with DSA frequently outselling it and Warhammer also being popular. I seem to recall Spain is similar with a major Spanish language game.
Nowadays in Spain, the main game is D&D, with Devir going fully 4e (funny how the same company can have so much different policies in different countries -Spain and Brazil-). In fact, Devir went 4e
before WotC, deciding to stop publishing 3.5 products when 4e was announced back in 2007.
Fantasy Flight's
Anima is a Spanish product, but it isn't very played here. And there's no much competition to D&D, apart from Spanish games and some translated games which aren't really supported (for example, we have
Mutants & Masterminds, but it's just the core book and
Freedom City.
Spanish games are usually well liked, but it isn't enough to make rpgs profitable here. We're talking about 1.000 sold copies as a really, really big success.
The main problem in Spain is that there's a very small market for Spanish-language products, so production costs are really high and it's very difficult to achieve success with anything else than the best seller of all.
That, and that we've a quite unique concept of "old school". Our "old schoolers" don't play 1e, but mainly RuneQuest or Aquelarre (Spanish game set in the Middle Age).
As for D&D, it seems to be quite successful, with some supplements already published. There are rumors of a Spanish publisher theoretically negotiating a Pathfinder translation, but nothing solid that I know...