I am thinking of 5.24 settings.
I just noticed the new Players Handbook mentions Dark Sun. Surprisingly. This seems to me, WotC decided not to discontinue it after all. I doubt they are rushing to publish it, but are open to it when they find ways to resolve some of its difficult content.
So, there is variety of D&D flavors.
Heh, one can have Vanilla, Natural Bean Vanilla, Homemade Vanilla, or French Vanilla: Forgotten Realms, Greyhawk, Dragonlance, or Nerath.
Then there are other distinctive flavors: Spelljammer-Planescape, Dark Sun, Eberron-Ravnica, Strixhaven-Witchlight-Feywild, Ravenloft-Shadowfell.
Now that the core really is setting neutral, I suspect some of the vanilla settings are free to diversify into neapolitan, chocolate chip, maybe even chocolate chip mint.
Whichever setting a table chooses will be the flavor of D&D.
I assume there will be a strong effort to make it easy for the options in one setting to import, and plug-and-play in an other setting. There will be advice for how a DM can do this for some of the more eccentric bespoke mechanics. In other words, 5.24 might be making the mythical 'modularity' a reality.
Right now, Eberron and maybe a new vision for Forgotten Realms are a good idea to reach most players. Forgotten Realms tends to appeal to traditionalist gamers and Eberron to modernist gamers. I suspect both will do deep dives into the flavors within the setting. Some of these deep dives will evolve via adventures for a setting. The two settings are a good start to getting the community into the habit of choosing a setting.
For the easiest flavor, DMs can use the Greyhawk setting in the DMs Guide.