Despite the name GURPS is very much not a universal system. There are things that I've found it does reasonably well but light-hearted action comedy isn't one of them. I thought it was the wrong system for Girl Genius when the game was first announced and I was sort of hoping the long delay meant it was never going to happen and something else would be used for the license.
Having read GURPS Discworld and seen what a mess that was as it tried to make Pratchett's world fit the GURPS rules... No, this won't work. There will of course be GURPS fans who claim otherwise and insist they're making it work fine just like they have with GURPS Discworld. And as with Discworld they just won't grasp that they're so familiar with GURPS the system has become transparent to them and doesn't really register in play, and that the fun they're having was in spite of the GURPS system and not because of it.
This isn't specifically a dig at GURPS players because I've seen it with other crunch-heavy systems too. People who play them regularly are so familiar with them that the mechanics no longer slow play down and it runs like a rules-lite game for them. And they can't see why anyone else would have trouble and not be willing to put in the effort to get to that same point or that there might be a system that does anything better than adapting what they like. All GURPS writers and GMs seem to be in that category for GURPS.
Sorry if this turned into a rant. I'm just anticipating the responses that experience has taught me GURPS fans will have whenever someone says that GURPS isn't the right system to run something.
Depending on the price I may end up getting this anyway. Despite my feelings about the GURPS ruleset I've got a fair number of GURPS sourcebooks because they tend to be pretty well researched and written, making them ideal reference material for running a game with another system.