Sure when I posted my first reply this was titled something more like Paizo - what you want.
So it that vain, and because its just popped into my head, a villains series!
An AP when the PCs are either cast as the rebellious underdogs (brigands who are reluctant heroes) and seen as villains by the wider society or
when the PCs work towards a goal that is certainly not good for the rest of the world (the return of some nasty power that promises them wealth, power, prestige, immortality). There might be a double cross at the end, but a 6 part AP where players can indulge their scheming, blackmailing side, that would be a breath of fresh air!