Vibes! Did my post not illustrate that lol?
But more seriously, the other two Holland-Spidey films are, respectively, a super-corporate and kinda dodgy* coming of age story which uses the superhero stuff as a backdrop (it's not a bad movie, to be clear - indeed it's pretty good when it sticks to the fun stuff), and an inept and confusing movie that's not sure what it is, but kind of wanted to a "European Vacation" movie then just gave up on that in favour of a sort of a technothriller that is nominally about Spider-Man.
Whereas No Way Home is absolutely centered on and focused in on what it means to be a superhero, and what it means to do the right thing, even if you don't really want to, even if it costs you emotionally, physically, in your connections to others and so on. It also does a great job of capturing the essence of Spider-Man's (strong) morality, which was largely absent from his previous MCU appearances (he's blandly a "good guy" and not much else in those), and really puts it at the heart of the movie. This is actual superheroism, not mere "nice guy in a bodystocking" stuff.
* = I am very sensitive to moral double-standards if a movie preaches.