Well... I was surprised to see the D&D books in their best-selling SF & fantasy, but honestly am not surprised/have no interest in the novels listed there.
The editor's picks, on the other hand, look really good. Ilium was almost certainly the best novel I read this year. Patricia McKillip and Greg Keyes are both great authors, and I just read Barnes' Lion's Blood, the book that comes before Zulu Heart, and it too was very good. So I think the editor who picked those knows his or her stuff... and they're probably all worth getting!