So you're currently running 3 games; 5e, 4e, and PF2e? Do you feel like it's hard keeping the rule differences clear between games since they're all the same genre? I feel like that would be hard, I know learning PF2e was a battle at first to forget the 5e-isms I had to remember how PF2e does things. 7 months in, I don't know if I could switch back and forth between PF2e and 5e rapidly on a week to week basis. I have run Call of Cthulhu and since it's a different genre and style of game, I find it a lot easier to remember how that game works.