The setting doesn't have to "Support" that. That's what Roleplaying is for. Roll yourself up a level 1 Noble Fighter and call yourself a Princess. It works just fine.Going to have to disagree.
I can't think of any other campaign setting where level 1 you start as ruling a kingdom. I mean you could do that in any campaign setting, but none of the rules or structure of the settings really support that. Cerilia is fractured into lots of small nations making politics an essential part of the setting much more so than any other settings you mention. The domain system is set up to support ruling a kingdom unlike every other setting. But not only are the countries fractured but the religions are as well, so you have multiple religions that worship the same god, but don't get along, adding a whole other level to the politics.
And politics, -again-, don't require a specific setting-based mechanic. Just decide which gods don't like each other on Faerun and it's all sorted out.
Don't elves -always- hate humans in any setting? Even when they "Like" them, they're still aloof and look down on humans...Then you have unique a halfling race that can step into the Shadow World, elves that hate humans with a passion, the whole bloodline mechanic, and blood theft. Also you have the issue with magic being attached to the natural state of the land, so the more developed a region is the less magical it is, the Battle Magic mechanics. The fact that the key monsters are unique, you don't have a load of Gorgons, you have The Gorgon.
There are loads of things special about it.
As far as Bloodlines and Blood Theft and the like WotC could probably drop a background and feat-line which does the same thing. And having unique monsters in a game is just saying "There's only one (of this specific kind of monster) in the world" which takes 7 whole words. Eight if the monster is a portmanteau.
I mean, honestly, couldn't you just remo-Best of all NO GNOMES, that alone is a huge selling point.
Birthright for 5e if you're not cowards, WotC!!!