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I mean, by the numbers, they sold like 8 million tickets in the US for HAT. In order to be successful, they needed to sell way, way more...but 8 million butts in seats is hard to do. The Barrier for "success" in modern Hollywood is extremely high.
Artistically, I think it could be done. Bit WotC has been very, very consistently down on the idea for their IP: official Magic and D&D stuff is going to be straight about the Settings, period.
WotC, on both the D&D and Maguc side, have been very firm for years that they want to play their IP straight, so new cutesy Meta player stuff will happen.
I think this hits the nail on the head: in the golden ahe of blockbusters, with more people going to theaters to see fewer big movies coming out...HAT would have had all the boxes tied. But nowadays even the MCU isn't working in theaters anymore.
The sale didn't seem to have much to do with D&D specifically, eOne had a lot of other stuff going on. The gist seems to be that Hasbro wanted control over film projects of their IP, but after trying that for a few years decided they didn't like the risk of actually fronting production money, so...
I've thought about exaxtly that. If I had infinite authority and resources, I would have them make a cartoon in the vein of those old Jason Thompson Adventure maps, one madcap episode per crazed dungeon:
I think the main value Alignment has is as a shorthand for DM prep and improv: knowing that rhe Vizier is Neutral Good, Neutral Evil, or Lawdul Neutral is helpful when improvising a response to player actions.